Ruth set the Major League Baseball single-season home run record four times, first at 29 (1919), then 54 (1920), 59 (1921), and finally 60 (1927).  Ruth's 1920 and 1921 seasons are tied for the widest margin of victory for a home run champion as he topped the next highest total by 35 home runs in each season. The single season mark of 60 stood for over 30 years until Roger Maris hit 61 home runs in 1961.  Maris' mark was in turn broken by both Mark McGwire and Sammy Sosa during the 1998 home run record chase , with McGwire ultimately setting the mark at 70.   Barry Bonds, who also has the most career home runs ,  set the current single season record of 73 in 2001.   The 1998 and 2001 seasons each had 4 players hit 50 or more home runs – Greg Vaughn , Ken Griffey, Jr. , Sosa, and McGwire in 1998 and Alex Rodriguez , Luis Gonzalez , Sosa, and Bonds in 2001.  A player has hit 50 or more home runs 42 times. Of these feats, 25 occurred since 1990.  The lowest home run total to ever lead a major league was four, a feat achieved in the NL by Lip Pike in 1877 and Paul Hines in 1878. 
Marshall McDougal, Florida State: The single-game home run king still holds the NCAA records for most home runs (six), hits (seven) and RBIs (16) in a contest after pacing the way in the 26-2 rout over Maryland. The second baseman finished with a .419 batting average that 1999 season (sixth in FSU single season history). He was later drafted by the Texas Rangers with the ninth overall pick in 2002 and played in 11 Major League games in 2005. He was 3-for-18 with a double while playing six different positions during his brief cup of coffee with the Rangers.