Dosing should be individualized based on disease and patient response:
Initial dose: 5 to 60 mg orally per day; may be give once a day or in divided doses
Maintenance dose: Adjust or maintain initial dose until a satisfactory response is obtained; then, gradually in small decrements at appropriate intervals decrease to the lowest dose that maintains an adequate clinical response
-Exogenous corticosteroids suppress adrenocorticoid activity the least when given at the time of maximal activity; consider time of maximal adrenal cortex activity (2 AM to 8 AM) when dosing.
-Alternate day therapy may be considered in patients requiring long-term treatment; it may be necessary to return to a full suppressive daily dose in the event of acute flare-ups.
Uses: As an anti-inflammatory or immunosuppressive agent when corticosteroid therapy is appropriate, such as treatment of certain allergic states; nervous system, neoplastic, or renal conditions; endocrine, rheumatologic, or hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, or gastrointestinal diseases; specific infectious diseases or conditions related to organ transplantation.
There are two major types of hormones produced by the adrenal gland , the mineralocorticoids and the glucocorticoids. This monograph discusses prednisone which is a synthetic glucocorticoid or corticosteroid. There are many different corticosteroid drugs available and different medical conditions are treated with different corticosteroid drugs based on the individual drug’s pharmacology (potency, speed of onset, duration of action). The other types of hormones produced by the adrenal gland are called mineralocorticoids. They primarily control salt and water balance in the body.