In the higher doses used to treat osteoporosis , plain sodium fluoride can cause pain in the legs and incomplete stress fractures when the doses are too high; it also irritates the stomach, sometimes so severely as to cause ulcers. Slow-release and enteric-coated versions of sodium fluoride do not have gastric side effects in any significant way, and have milder and less frequent complications in the bones.  In the lower doses used for water fluoridation, the only clear adverse effect is dental fluorosis , which can alter the appearance of children's teeth during tooth development ; this is mostly mild and is unlikely to represent any real effect on aesthetic appearance or on public health.  A chronic fluoride ingestion of 1 ppm of fluoride in drinking water can cause mottling of the teeth (fluorosis) and an exposure of ppm will produce mottling in 30–50 % of patients. 
Results of analysis of the performance of the two protocols by assessing the accuracy of the CT number, noise, low contrast resolution and spatial resolution showed that high-dose protocol has better performance than low-dose protocol. Image with high-dose protocol has an average GM conspicuity of and CNR , while the image with a low dose of and at CNR. Comparison of gray scale image of the protocol through the image histogram comparison homogeneous phantom and patient image shows that the image of a low-dose protocol has variation of intensity gray value that is wider than high-dose protocol.