High dose inhaled corticosteroids

Valve. A clear understanding of the exact composition and functionality of the reference marketed product’s valve allows for selection of an appropriate valve for the generic pMDI product. Differences in the valve may affect factors such as formulation compatibility and pharmaceutical performance.  
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the title of the article is self explanatory: High Dose Hydrogen, Magnesium, Bicarbonate Therapy
ph adjust is about the mag/bicarb part. Frankly I wonder if the hydrogen is necessary since bicarb also contains H.
I used to drink h2o2 and I now see it is an inferior protocol to the bicarbs after having tried both. I found I got hydrated with the latter and not the former. I buy mag carbonate and sodium bicararbonate by the kilo . I mix the magcarb with lime and ascorbic acid, then mix that with a sodbicarb, water, lime and stevia solution to taste and drink throughout the day..wonderful. I figure I get enough potassium in my foods already but you could add potassium bicarb if you want. The bicarb part of the molecule is the key to the hydration. Bicarbs are simply natural, powdered limestone.

31 papers reporting the results of 26 trials were included in the review . For studies that compared a step down approach to a constant moderate/low ICS dose, there were no significant differences in lung function, symptoms, rescue medications or asthma control between the two treatment approaches. Significant but clinically small improvements in percent predicted FEV1 ( WMD , 95% CI to ) and non significant improvements in the change in morning PEF were found for high dose ICS compared to moderate dose ICS. There were no significant differences in efficacy between high and low dose ICS. For moderate dose ICS, compared to low dose ICS, there were significant improvements in the change in morning PEF l/min from baseline (WMD , 95% CI to ) and nocturnal symptoms (SMD -, 95% CI - to - ) . Commencing ICS at double or quadruple a base moderate or low dose had no greater effect than commencing with the base dose. Several studies reported greater improvement in airway hyperresponsiveness for high dose ICS.

Why it matters : Latest BTS/SIGN guidance on the treatment of asthma recommends that patients should be maintained at the lowest possible dose of inhaled corticosteroid. Reduction in inhaled corticosteroid dose should be slow as patients deteriorate at different rates. Reductions should be considered every three months, decreasing the dose by approximately 25–50% each time. 'High-dose' inhaled corticosteroids are listed at step 4 of the guidelines. The latest guidance for treatment of COPD now recommends use of another treatment in preference to inhaled corticosteroids. There is some evidence that inhaled corticosteroids increases the risk of pneumonia. This risk appears to increase with dose.

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High dose inhaled corticosteroids

high dose inhaled corticosteroids

Why it matters : Latest BTS/SIGN guidance on the treatment of asthma recommends that patients should be maintained at the lowest possible dose of inhaled corticosteroid. Reduction in inhaled corticosteroid dose should be slow as patients deteriorate at different rates. Reductions should be considered every three months, decreasing the dose by approximately 25–50% each time. 'High-dose' inhaled corticosteroids are listed at step 4 of the guidelines. The latest guidance for treatment of COPD now recommends use of another treatment in preference to inhaled corticosteroids. There is some evidence that inhaled corticosteroids increases the risk of pneumonia. This risk appears to increase with dose.

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