One of the main drawbacks with this drug is that after a couple of weeks it seems to stop working for most people. This is due to the fact that it can cause a down regulation of the beta-receptors in the pulmonary, cardiac and Central Nervous System (CNS). One way to detect this down regulation is when you no longer feel an elevation in body temperature following administration. This would suggest that the substance is no longer exhibiting a thermogenic effect. At this point increasing the dosage would not be very effective and a break of at least two weeks should be taken before it's used again. This accounts for the popular two weeks "on"/two weeks "off" method of administration. However, much controversy exists in this area. Some say clenbuterol can promote fat loss for approximately 4-6 weeks, though any strength gains can usually only be felt for 3-4 weeks. While clenbuterol appears to stop working after a few short weeks, the reality of situation is that it never stops working. It may lose some of it initial potency, but the fat-burning properties do continue, even as long as 16 weeks after its initial use.
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