Mineralocorticoid activity of steroids

Exelixis, Inc. (NASDAQ: EXEL) is a biopharmaceutical company committed to the discovery, development and commercialization of new medicines with the potential to improve care and outcomes for people with cancer. Since its founding in 1994, three medicines discovered at Exelixis have progressed through clinical development to receive regulatory approval. Currently, Exelixis is focused on advancing cabozantinib, an inhibitor of multiple tyrosine kinases including MET, AXL and VEGF receptors, which has shown clinical anti-tumor activity in more than 20 forms of cancer and is the subject of a broad clinical development program. Two separate formulations of cabozantinib have received regulatory approval to treat certain forms of kidney and thyroid cancer and are marketed for those purposes as CABOMETYX™ tablets (.) and COMETRIQ ® capsules (. and EU), respectively. Another Exelixis-discovered compound, COTELLIC ® (cobimetinib), a selective inhibitor of MEK, has been approved in major territories including the United States and European Union, and is being evaluated for further potential indications by Roche and Genentech (a member of the Roche Group) under a collaboration with Exelixis. For more information on Exelixis, please visit or follow @ExelixisInc on Twitter.

The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile . [22] [23] [24] The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation , by Arthur Nobile and coworkers. [25] They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone . [26]

Licorice root has the following actions:

  • Relaxing expectorant (soothes coughs)
  • Demulcent (soothing effect on contact)
  • Anti-inflammatory (via the body's own corticosteroid mechanisms)
  • Antiulcer against gastrointestinal ulcers
  • Laxative
  • Adaptogen tonic (increases resistance to the effects of physical, mental and emotional stress)
  • Hepatoprotective (protects the liver)
  • Antiviral, antifungal, antibacterial
  • Antioxidant and antitumor
  • Hormonal regulation
    Conditions commonly used for
  • Digestive disorders - Peptic ulcer, ulcerative colitis, Crohn's disease, chronic gastritis, heartburn, constipation
  • Immune - infections, including hepatitis, herpes, urinary tract infections, respiratory infections, allergies, autoimmune disorders
  • Inflammatory conditions - including eczema, psoriasis, arthritis, asthma, systemic lupus erythematosus
  • Primary adrenocortical insufficiency, Addison's disease
    Common dosage range Generally recommended doses range from 1 to 5 g of dried root, as infusion or decoction three times per day. Deglycyrrhizinated extracts are often utilised for peptic ulcer, with each product stating it's own dosage range.

Mineralocorticoid activity of steroids

mineralocorticoid activity of steroids


mineralocorticoid activity of steroidsmineralocorticoid activity of steroidsmineralocorticoid activity of steroidsmineralocorticoid activity of steroidsmineralocorticoid activity of steroids