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Bernice Hibbert (voiced by Tress MacNeille ) [19] is Dr. Julius Hibbert 's wife and is loosely based on the Clair Huxtable character from The Cosby Show . [20] The Hibberts have three children, two boys and a girl. Nevertheless, her marriage is on the rocks; [21] she refuses to kiss her husband, even in front of an entire audience. [22] Her drinking has been joked about on several occasions. She fainted when she read that "Prohibition" had been introduced to Springfield [23] and attends Springfield Alcoholics Anonymous meetings. [24]

The differential diagnosis ( Table 3 30 , 32 ) of early erythema multiforme includes drug eruption, polymorphic light eruption, urticaria, urticarial vasculitis, viral exanthems, and other hypersensitivity reactions. 32 Because erythema multiforme often resembles urticaria at the onset of the eruption, it is important to distinguish the clinical features. The individual lesions of erythema multiforme in typical cases are present and fixed for at least one week, and some evolve into target lesions. 33 In contrast, the individual lesions of urticaria exist at the same site for less than 24 hours, 8 and the centers of the lesions appear normal or as red as the borders. 6 Target lesions with dusky or purpuric centers may resemble pityriasis rosea, lupus erythematosus, vasculitis, or figurate erythema. 32 When bullous lesions are present, erythema multiforme must be distinguished from the autoimmune bullous diseases. 31

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