Pharmacologie anti inflammatoires non steroidiens

Omeprazole is a racemate and exists in two optical isomers in the S- and R-configuration. The S-isomer generates higher plasma-levels than the R-isomer, due to lower metabolic  conversion by hepatic cytochromes (CYP2C19). The active molecular species, the sulphenamide, is non-chiral and equipotent after generation from both isomers. Thus, higher bioavailability and not higher intrinsic activity of the S-isomer (as in esomeprazole) explains the stronger inhibitory action of S-omeprazole observed at the molecular target site inside the parietal cells.

Pharmacologie anti inflammatoires non steroidiens

pharmacologie anti inflammatoires non steroidiens

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