If any of the following serious side effects occur, stop giving prednisolone and seek emergency veterinary medical attention: an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), increased blood pressure, or sudden weight gain. Other less serious side effects may occur. Continue giving prednisolone and talk to your veterinarian if your pet experiences insomnia, nausea, vomiting or stomach upset, fatigue, muscle weakness or joint pain, problems with diabetes control, or increased hunger or thirst. Other side effects that occur rarely, usually with high doses of prednisolone include thinning of the skin, cataracts, glaucoma, or behavior changes. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
Lupus arthritis is often first treated with nonsteroidal anti-inflammatory medications (NSAIDS) , such as ibuprofen or naproxen. If the patient does not have a good response or there are contraindications to the above medications, short courses of low doses of glucocorticoids (., 5-10 mg of prednisone) may be used. In unresponsive cases, Disease-Modifying Antirheumatic Drugs (DMARDs) such as methotrexate and azathioprine may be used. The rheumatologist usually makes decisions about the different therapies based on whether other organs are also involved by the disease.